KLRB1 and central nervous system cancer: In addition, there are literatures revealing that the functional characteristics of T cells verified in glioma are also applicable to other types of tumors (melanoma, non-small cell lung cancer and colon cancer) (Inhibitory 2021; Wyrozemski and Qiao 2021; Braud et al. 2022), which suggests that CD161 can be used as a tumor infiltration function targets for immunotherapy in T cells.