TBC1D3, shares high homology with other TBC domain genes that contribute to colorectal cancer carcinogenesis through M2 macrophage infiltration, creating an immunosuppressive tumor microenvironment that facilitates immune evasion and tumor progression.31,32 Similarly, mesothelin (MSLN) is associated with immune inhibition in CC, allowing cancer cells to proliferate undetected.33 Furthermore, the pathway enrichment analysis demonstrated that Black patients with localized disease had downregulation of the IL-17 and cytokine-cytokine receptor interaction pathways. Here, MSLN is linked to neoplasm.