GABRA3 (GABA type A receptor subunit alpha3) was significantly overexpressed in Black patients with localized disease, and GABA receptor antagonists, such as flumazenil, exhibit antiproliferative effects.36,37 Similarly, the activity of HTR2C (serotonin 2C receptor), which is upregulated in Black patients, could be inhibited with Mirtazapine, which showed reduced tumor growth and prolonged survival in in vivo studies.38,39 PAX7 is another promising therapeutic target. This evidence concerns the gene GABRA3 and neoplasm.