Specifically, we found that PRSS21 overexpression in Black patients with metastatic disease was co-upregulated with two other genes, MT4-MMP and SBSPON, both associated with aggressive tumor behavior.23–25 This suggests that having a gene expression profile with upregulation of these genes may predict high tumor invasiveness in Black patients. The gene discussed is PRSS21; the disease is metastatic neoplasm.