Suppression of IL-17 signaling leads to increased recruitment of CD8+ cytotoxic T lymphocytes (CTLs) to colorectal tumors through upregulation of chemokines CXCL9 and CXCL10.34 IL-17 suppression also results in increased infiltration of regulatory T cells (Tregs) in the tumor microenvironment. The gene discussed is CXCL10; the disease is colorectal neoplasm.