The APT/PC group could be further separated into three pituitary cell lineage-driven subclusters: (1) the PIT1 subcluster, which contained 35 PIT1 specimens (26 APT, out of which 7 NF-APT, and 9 PC, out of which two NF-PC) and one F-TPIT PC; (2) the TPIT subcluster, which contained 29 TPIT specimens (21 APT, out of which three silent and 8 F-PC) and one sample from the TPIT/SF1-positive NF-APT, also classified as ACTH-producing adenoma in the Heidelberg classifier; and (3) the SF1 subcluster, which included one SF1 NF-APT sample and two SF1/PIT1 APT specimens (one NF-APT and one F-APT). The gene discussed is POMC; the disease is adenoma.