PPARA and obesity due to melanocortin 4 receptor deficiency: Interestingly, eWAT progenitor cells had downregulated pathways such as transforming growth factor β (TGF-β) signaling, conceivably reflecting a decrease in the progenitor fibroinflammatory profile (Figure 4C).9 In contrast, the reversed pathways that were downregulated in obesity but upregulated by Rosi were related to pathways such as PPAR signaling and adipogenesis pathways (Figure 4D).