Elevated PI3K expression, increased Akt phosphorylation, and reduced phosphatase and tensin homolog (PTEN) levels have been observed in ectopic and eutopic endometria of patients with endometriosis, especially in those with minimal to mild disease, highlighting the role of the PI3K/Akt/mTOR pathway in the onset of endometriosis (Madanes et al., 2020). This evidence concerns the gene PTEN and endometriosis.