Additionally, in cultures of epithelial and stromal cells derived from human deep-infiltrating endometriosis and in a nude mouse transplantation model, cell proliferation was associated with increased endogenous oxidative stress and activation of the extracellular signal-regulated kinase (ERK) and mTOR/AKT pathways, and mTOR inhibitors demonstrated therapeutic effects (Leconte et al., 2011). The gene discussed is AKT1; the disease is endometriosis.