Examples include G1/S-specific cyclin-E1 and cyclin-dependent kinase 14, which regulates the transition between phases G1 and S of the cell cycle (Chen et al. 2019; Fagundes and Teixeira 2021), ST7 and TRIM33 that act as tumor suppressor genes (Charong et al. 2011; Xue et al. 2015), and Kruppel-like factor 6, a transcription factor involved in the progression of multiple malignant tumors (Sabatino et al. 2019). The gene discussed is KLF6; the disease is cancer.