In the GISSI‐HF cohort, when Ln‐transformed NT‐proBNP was included, a significant association was observed with all‐cause death (HR 1.79, 95% CI 1.14–2.81) and MACE (HR 1.62, 95% CI 1.00–2.63) for individuals in the highest CERT2 risk score category. Here, NPPB is linked to hydrops fetalis.