HLA-DQB1 and Hepatic fibrosis: In contrast, the most affected independent variant is rs9274407, within the HLA-DQB1 gene, which has demonstrated a robust association with an increased risk of liver fibrosis (OR = 1.26, 95% CI 0.05–1.15), and it has been previously reported as a susceptibility variant with an increased risk of drug-induced liver injury [29].