GH1 and metabolic disease: This serious metabolic disorder primarily emanates from a complex interplay of factors including insulin resistance, disrupted hepatic gluconeogenesis, and a progressive decline in B-cell insulin secretion [1].Over the preceding decade, the scientific community has increasingly focused on the potential involvement of Growth Hormone (GH) and Insulin-Like Growth Factor-1 (IGF-1) in the pathogenesis and progression of Type 2 Diabetes Mellitus (T2DM).