Given that WRN is a known essential gene in MSI cancer cell lines [8, 60, 62, 63, 122], we investigated whether microsatellite status played a role in the SL interaction predicted between WRN and KMT2D. To this end, we used MSI status to stratify the WRN KO lethality probability scores of KMT2DLOF cell lines and KMT2DWT cell lines from the pan-cancer dataset. The gene discussed is WRN; the disease is cancer.