Strikingly, compared to KMT2DWT cancer cell lines with microsatellite instability (MSI), we show that KMT2DLOF MSI cell lines are more sensitive to WRN KO and thus, as predicted, to treatment with two recently published WRN inhibitors, which are in phase I clinical trials (NCT05838768 [16] and NCT06004245 [17]). Here, WRN is linked to cancer.