Although we did not find a difference in PER2 expression, PER2-regulated glycolytic genes, namely CDK1, ENO1, GAPDH, LDHA, and PGAM1 [117], all showed either a trend towards or a statistically significant mRNA expression elevation in KMT2DLOF cases compared to KMT2DWT cases, consistent with results demonstrated by Alam et al. [117] in a Kmt2d knockdown mouse lung cancer cell line (Fig. 3A; Additional file 7: Table S6; Methods). Here, ENO1 is linked to lung cancer.