On the other hand, KMT2D protein expression in KMT2DLOF cell lines was significantly lower in the pan-cancer dataset and trended lower than in KMT2DWT cell lines across all nine cancer type-specific datasets for which data were available, including COAD/READ, LUSC, SCLC, STAD, and UCEC (Fig. 2B). The gene discussed is KMT2D; the disease is cancer.