EXOSC5 and endometrial cancer: Additionally, exosomes released by endometrial cancer cells, containing Exosome component 5 (EXOSC5), can target netrin4 (NTN4) and bind to integrin β1, activating the FAK/SRC/β-catenin signaling axis and enhancing c-MYC activity, which in turn strengthens CSC properties and promotes tumor progression [72].