However, ultrasound, AFP and other serum biomarkers, such as protein induced by vitamin K absence or antagonist-II (PIVKA-II) (previously des-γ carboxyprothrombin [DCP]) and Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), have demonstrated limited sensitivity for detection of HCC when used as standalone indicators22–25. The gene discussed is AFP; the disease is hepatocellular carcinoma.