Thus, surprisingly, these major characteristics of Cushing’s syndrome are not directly mediated by the action of glucocorticoids on metabolically active cell types (such as adipocytes, hepatocytes and muscle cells) but apparently require the obligatory contribution of extracellular ACBP/DBI (that can be inhibited by neutralizing antibodies) acting on GABAAR receptors containing the GABRG2 subunit. The gene discussed is GABRG2; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.