The whole-body Acbp/Dbi knockout14 rendered circulating ACBP/DBI and hepatic Acbp/Dbi mRNA undetectable (Fig. 3b,c), reduced CORT-induced appetite (Fig. 3d) and weight gain (Fig. 3e) and had no effects on CORT plasma levels (Supplementary Fig. 4a), but attenuated the CORT-induced hepatomegaly, expansion of adipose tissues, atrophy of the skeleton muscle, dyslipidaemia, insulin resistance fasting plasma glucose, HOMA-IR values and alterations in the GTT and ITT (Fig. 3f–j and Supplementary Fig. 4). Here, DBI is linked to inherited lipid metabolism disorder.