Shared fibrillar-associated genes in the cortex include NEFH, NEFM, ALDOC and MAFB. Notably, meta-module M11’s hub genes VIM and CLU were among the shared amyloid-associated genes, and M11’s expression weakly correlated with amyloid hotspots (max Pearson correlation R = 0.131 in L5/L6 early-stage AD, R = 0.187 in ctx deep layers in 6 month 5xFAD), implicating it in cross-species amyloid-associated processes (Supplementary Fig. 56). Here, NEFH is linked to Alzheimer disease.