Independently of the NTD phenotype, Tet1 KO embryos displayed significantly reduced crown-rump (CR) length compared to WT and HET embryos (Fig. 1D), otherwise no overt differences were observed between NTD-affected and unaffected (normal) Tet1 KO E11.5 embryos (Appendix Fig. S1B). The gene discussed is TET1; the disease is neural tube defect.