In an additional pan-cancer dataset (ICGC, TCGA, Pan-cancer whole genome analysis, Nature 2020) [35], we found that HNSCC patients had the second highest BIRC2 and BIRC3 mutation frequency among 27 types of cancers with a prevalence of 14.29% (Supplementary Fig. 1A), similar to Eytan et al. [19]. The gene discussed is BIRC3; the disease is head and neck squamous cell carcinoma.