BIRC3 and neoplasm: However, despite the absence of significant differences in BIRC3 mRNA levels between tumor areas and normal epithelium in the TCGA database (P < 0.0001), high expression levels of cIAP2 were observed specifically in OSCC tumor areas compared to normal epithelium (P < 0.0001) (Fig. 2B, Supplementary Fig. 2F).