BIRC2 and metastatic malignant neoplasm in the lymph nodes: Furthermore, multivariate Cox regression analysis adjusted for established clinical risk factors (eg. age at diagnosis, TNM stage, pathological stage, local recurrence, and distant metastasis) indicated that lymph node metastasis (HR = 3.31, P = 0.009), distant metastasis (HR = 2.802, P = 0.013) and high expression of cIAP1 (HR = 2.608, P = 0.035) were risk factors for OS in OSCC (Supplementary Table 3).