Studies have revealed that hepatocellular cell-derived extracellular vesicles coated with microRNA-584-5p activate the NRF2(Nuclear Factor erythroid 2-Related Factor 2) signaling pathway by inhibiting the expression of PCK1 and increasing the expression of VEGF, VEGFA, VEGFR2, and other proangiogenic factors to promote angiogenesis in tumor tissues [75]. Here, PCK1 is linked to neoplasm.