ZBTB22 and hepatocellular carcinoma: Before the development of HCC, P53, SHP-1(Src homology 2 domain-containing protein tyrosine phosphatase 1), ZBTB22(Zinc finger and BTB domain containing 22), and NFY(Nuclear Factor Y) can act as transcriptional coactivators of PCK1, controlling hepatic glucose production and regulating glucose homeostasis [83–86].