In HCC, PCK1 promotes the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway, and the methyltransferase SUV39H1 catalyzes SAM as a methyl donor to support H3K9me3 modification, thereby repressing the oncogene S100A11 [22] (Fig. 2). The gene discussed is PCK1; the disease is hepatocellular carcinoma.