PCK1 deficiency in HCC inactivates AMPK(Adenosine 5‘-monophosphate (AMP)-activated protein kinase), inhibits p27kip1 expression, and stimulates the CDK/Rb/E2F pathway to promote cell proliferation, thereby accelerating the cell cycle transition from G1 to S phase under glucose starvation conditions [90]. Here, PCK1 is linked to hepatocellular carcinoma.