MMP9 and hepatocellular carcinoma: Additionally, KAT5 O-GlcNAcylation epigenetically activates TWIST1 expression through histone H4 acetylation and enhances MMP9(Matrix metalloproteinase-9) and MMP14(Matrix metalloproteinase-9) expression through c-Myc acetylation, thereby promoting EMT in HCC [41].