In the 1st batch, the top three proteins most strongly and positively associated with IHD were NTproBNP (adjusted HR: 1.81, 95%CI 1.60–2.04, per 1 SD higher concentration), WFDC2 (1.66, 1.46–1.88) and ADM (1.56, 1.34–1.82), while the top two proteins most strongly inversely associated with IHD were CNTN5 (0.78, 0.70–0.88) and AFP (0.82, 0.73–0.92: Fig. 2, Fig. 3). This evidence concerns the gene NPPB and myocardial ischemia.