Our results revealed a significant elevation in SENP2 expression within breast cancer tissue cells, characterized by an H-score value substantially surpassing that in corresponding adjacent tissues (Fig. 1E and F, and S1), and SENP2 expression was highly correlated with the stages of breast cancer progression (Fig. 1F), indicating that SENP2 was up-regulated in breast cancer tissues. Here, SENP2 is linked to breast cancer.