MAPK1 and breast carcinoma: Examination of putative SENP2 target proteins revealed that ERK2 is primarily SUMOylated by SUMO2 and that SENP2 deconjugates the SUMOylation of ERK2, increasing the stability and activity of ERK2 and ultimately promoting the epithelial-to-mesenchymal transition (EMT) and the progression of breast carcinoma.