The results showed that overexpression of SENP2 rescued the inhibited cell growth and migration of cancer cells induced by the miR-145-5p mimic (Fig. 7I and J), substantiating the assertion that miR-145-5p operates as a pivotal agent in impeding the progression of breast cancer through down-regulating SENP2 levels. The gene discussed is SENP2; the disease is breast cancer.