ALAS2 and neuropathic pain: This finding, which partly matches a recent study showing a significant down-regulation of Hba-a1, Hba-a2, and Alas2 in the dorsal root ganglia of mice injected with a single dose of oxaliplatin (Gould et al, 2021), further implicates the down-regulation of these genes in neuropathic pain physiopathology and suggests that oxaliplatin may participate in blocking the hypoxic response in addition to its induction of nerve vasoconstriction.