KEGG analysis demonstrated that the role of ENO1 in carcinoma pathogenesis may be associated with carbon metabolism, amino acid biosynthesis, the hypoxia-inducible factor-1 (HIF-1) signaling pathway, the metabolic pathway, central charcoal anabolism, the pentose phosphate pathway, nucleotide anabolism, cellulose and mannose anabolism, and the glucagon signaling pathway (Fig 3E). Here, GCG is linked to carcinoma.