ENO1 and carcinoma: KEGG analysis demonstrated that the role of ENO1 in carcinoma pathogenesis may be associated with carbon metabolism, amino acid biosynthesis, the hypoxia-inducible factor-1 (HIF-1) signaling pathway, the metabolic pathway, central charcoal anabolism, the pentose phosphate pathway, nucleotide anabolism, cellulose and mannose anabolism, and the glucagon signaling pathway (Fig 3E).