On the other hand, CD8+ cell densities were significantly (p < 0.001) lower in the ER+HER2– BC with lower variance in all IZ aspects and a more pronounced drop of the density at the tumor aspect; one could suggest that this pattern, in general, reflects a lower CD8+ cell response and CD8+ cell penetration into the tumor compartment. The gene discussed is CD8A; the disease is neoplasm.