Similarly, Lu et al. [23], in a comprehensive study of 2,081 patients with early‐stage ER+HER2− BC, reported that the Ki67 colocalization score, measured by the Shannon diversity index, could significantly stratify patients with regard to BCSS and distant metastasis-free survival, emphasizing the potential of ITH assessment over the standard Ki67 index. Here, ESR1 is linked to breast cancer.