Indeed, it was demonstrated that CD74 regulates an anti-inflammatory pathway in melanoma promoting a tolerogenic phenotype of both DCs and macrophages; supports the regulatory T cell accumulation in several tumors; and hampers the M1 polarization of the microglia in brain metastasis from non-small cell lung cancer (NSCLC) [56,68,69]. The gene discussed is CD74; the disease is non-small cell lung carcinoma.