Since deficiency of CD74 results in a reduced number of mature B cells and CD4+ T cells [37], we next wished to determine whether the reduced tumor load detected in the CD74-deficient mice results from the lack of immune cells that are able to control the antitumoral response, or whether it is due to the role of CD74 as a MIF receptor, regulating the function of immune cells. Here, CD74 is linked to neoplasm.