In non-ultramutated endometrioid ECs, ALK5 mutations were found in all tumor grades: 14.3% (2 of 14) of grade 1; 21.4% (3 of 14) of grade 2; and 64.3% (9 of 14) of grade 3 tumors. The gene discussed is TGFBR1; the disease is neoplasm.