In MCF7 control, the phosphorylated form of NF-kB was not detected and exclusively increased under hypoglycemia (2 mM) in the resistant variants of MCF7-4xAC and MCF7-4xAC+4xPAC cells (Fig 5), consistent with the fact that the higher expression of p-NF-kB is correlated with more resistant cells to chemotherapy [39]. Here, NFKB1 is linked to Hypoglycemia.