However, the opposing idea that endogenous GIP is pro‐adipogenic is supported by findings that mice lacking Gipr are protected against diet‐induced obesity (Miyawaki et al., 2002) and that humans with loss of function GIPR variants have a lower average body mass index (Kizilkaya et al., 2024). This evidence concerns the gene GIPR and obesity due to melanocortin 4 receptor deficiency.