In the tumor microenvironment, MSCs can promote tumor progression by enhancing the recruitment of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), as well as by promoting angiogenesis through the secretion of vascular endothelial growth factor (VEGF) and other pro-angiogenic factors, which support tumor growth and metastasis [16]. This evidence concerns the gene VEGFA and neoplasm.