PDPN and cancer: In the former, cancer cells release tissue factor (TF) and the fibrinolysis inhibitor plasminogen activator inhibitor 1 (PAI1), express podoplanin (PDPN), which binds to and activates the C-type lectin-like receptor 2 (CLEC2) on platelets, and expose phosphatidylserine that promotes coagulation by forming a surface for coagulation complexes.