In support of our finding, accumulating evidence suggests that these thin and highly polarised cytonemes can also operate in other contexts, such as during the transport of Wnt8a proteins in zebrafish gastrulation (Brunt et al., 2021; Stanganello et al., 2015), Wnt2b in the mouse intestinal crypt (Mattes et al., 2018), WNT3A in human embryonic stem cells (Junyent et al., 2020), Wnt3 in gastric cancer (Routledge et al., 2022), and Wnt5a in cancer-associated fibroblasts (Rogers et al., 2023) as well as in zebrafish development (Zhang et al., 2024). The gene discussed is WNT3; the disease is cancer.