TRPV5 and Hypercalciuria: The importance of TRPV5 is evidenced by Trpv5 knockout mice, which present with severe hypercalciuria, together with bone abnormalities, significantly higher levels of 1,25‐dihydroxyvitamin D3 and compensatory intestinal Ca2+ hyperabsorption (Hoenderop et al., 2003; Renkema et al., 2005).