PREG activates pregnane X receptor (PXR), particularly in the gut,119 promoting anti‐inflammatory responses and potentially playing a role in gastrointestinal and autoimmune disorders like type 1 diabetes (T1DM), where low PREG levels correlate with PXR dysfunction and cognitive impairment.120, 121, 122. This evidence concerns the gene NR1I2 and Cognitive impairment.