Notably, Cyp11a1 and Cyp11b1 mRNA are expressed both in a murine intestinal epithelial cell line35 and in human colon biopsies,36 underscoring the importance of investigating steroid metabolism beyond to glucocorticoids, particularly in pathological contexts such as the inflammatory bowel disease (IBD) and functional gastrointestinal disorders (FGIDs). Here, CYP11B1 is linked to inflammatory bowel disease.