This, in conjunction with chemokines such as chemokine (C-C motif) ligand 2 (CCL2) and chemokine (C-C motif) ligand 20 (CCL20), augments the capacity of HEV to recruit lymphocytes, thus fostering the development and maturation of TLS within the context of human CRC [53,54] (Figure 1). This evidence concerns the gene CCL20 and colorectal carcinoma.