The cytokines interleukin-17 (IL-17) and interleukin-22 (IL-22), key players in Th17 cell function, with IL-17A, a variant of IL-17, being particularly implicated in the advancement and angiogenesis of CRC through the signal transducer and activator of transcription 6 (STAT6) signaling pathway [37]. This evidence concerns the gene IL22 and colorectal carcinoma.