LGALS3 and preterm premature rupture of the membranes: However, another study supports that, compared with healthy pregnant women, low Gal‐1 maternal serum level has been associated with the incidence of PPROM [27]; however, there is also information suggesting that maternal serum Gal‐1 and Gal‐3 levels are significantly higher in pregnancies complicated with PPROM, which was interpreted as a possible regulatory effect in key biological processes may be an initiating factor in the pathophysiology of PPROM, a marker in its prediction, and a target of PPROM prevention strategies [27, 37].