NOS3 and aneurysm: Small molecules that enhance endothelial nitric oxide synthase (eNOS) activity or inhibit endothelial cell apoptosis, Hemodynamic stress, oxidative stress, estrogen imbalance, and endothelial cell-to-cell junction impairment are among the connected factors underlying EC dysfunction can improve vascular integrity and reduce aneurysm risk (Sheinberg et al., 2019).