It was found that the tamoxifen-suppressed hepatic very low-density lipoproteins-triglyceride (VLDL-TG) secretion, as well as hepatic apolipoprotein B (ApoB), microsomal triglyceride transfer protein (Mttp), and phospholipase A2 G12B (Pla2g12b) expression in female C57BL/6 mice were rescued by enforced ERRα expression, implying that decreased ERRα expression was a contributing factor to tamoxifen-induced NAFLD (Yang M. et al., 2020). This evidence concerns the gene ESRRA and metabolic dysfunction-associated steatotic liver disease.