Although E2 treatment partially restored the levels of TNF-α, C-reactive protein (CRP), and endothelial nitric oxide synthase (eNOS) in OVX T2DM rats to exert a specific vasoprotective effect, the effect was not as significant as that observed with a selective ERα agonist, propyl pyrazole triol (PPT) (Bansal and Chopra, 2018). The gene discussed is ESR1; the disease is type 2 diabetes mellitus.