FAP+ CAFs are the main repository for CXCL12 in PDAC tumor microenvironment: CXCL12 promotes T cell spatial exclusion, and pharmacological inhibition of CXCL12-CXCR4 interaction results in T cell accumulation in tumor tissue and fostering of immune checkpoint blockade (92). The gene discussed is CXCR4; the disease is neoplasm.