CD44 and neoplasm: As observed in tumor cell profiling, immune cell composition of the TME is heterogeneous among the analyzed patients: neutrophil abundance was higher in PDAC #1, (29.4%) #2 (20.5%), #3 (9.8%) and #6 (15.9%); PDAC #2 showed a highest frequency of both M1-like (24.4%) and M2-like (26.8%) macrophages; CD44+ were abundant in PDAC #4 (35.9%) and #8 (19.5%) (Supplementary Figure 4C).