Figure 6F show the concomitant infiltration of podoplanin+ cadherin-11- CAFs 5 (white arrow) and podoplanin+ cadherin-11+ CAFs 12 (white arrowheads), close to tumor cells. Finally, CAFs 1, expressing the conventional pericyte markers, are associated with higher CA19-9 levels and worst patients prognosis (padj<0.001)(Figures 6A-D; Supplementary Figure 6). On the other hand, CD44+ CAFs 8, vimentin+ CAFs 15 and apCAFs (CAFs 16) are associated with lower CA19-9 levels, as well as longer DFS and survival (padj<0.001) (Figures 6A-D; Supplementary Figure 6). The gene discussed is CD44; the disease is neoplasm.