Additional markers included CD206, CD163 and HLA-DR, to reveal a functional state of tumor-associated macrophage (TAM) (M1 versus M2 polarization), whereas evaluation of carbonic anhydrase 9 (CA-IX) expression defined the cancer cell capable in sustaining local acidosis, and hence in favoring cancer progression (34) (Supplementary Figure 1A). The gene discussed is MRC1; the disease is neoplasm.