Interestingly, a cancer-derived PTX3 production has been associated with tumor progression in several type of cancer, including melanoma, cervical cancer, hepatocellular carcinoma and glioma (44, 45, 73, 74), possible consequence of its role in remodeling ECM (75–77) that occurs in acidic microenvironments (76), an hallmark in cancer (78). This evidence concerns the gene PTX3 and hepatocellular carcinoma.