Noteworthy, distribution of macrophages around Pan-Ck tumor cells is shown in Figure 3F, with M2-like macrophages expressing higher levels of CD163 and CD206 (Figure 3F, white arrows) and M1-like macrophages expressing higher levels of HLA-DR and CD74 (Figure 3F, white arrowheads). This evidence concerns the gene CD74 and neoplasm.