Interestingly, we found that the Tumor 5 (12.9%, range 0-43.7% per PDAC, Figure 2D), expressing Pan-Ck, Ck-7 and PTX3 was almost exclusively found in PDAC #1 and #3 only, counting for the 90% of all identified Tumor 5 cells (Figure 2E), who were diagnosed with distant metastasis at the time of surgery (Supplementary Table 1). This evidence concerns the gene PTX3 and neoplasm.