We then compared the transcriptional alterations in patients with high- and low- risk scores classified by our CDRscore model, and Gene Set Enrichment Analysis (GSEA) showed that most immune response associated pathways, such as T/B cell receptor signaling pathway and Intestinal immune network for IgA production, were significantly down-regulated in patients with high-risk CDRscore, nevertheless, the tumor development related pathway, including epithelial mesenchymal transition, ECM receptor interaction, angiogenesis, TGF-β signaling and hypoxia, were significantly up-regulated (Figure 6B). Here, TGFB1 is linked to neoplasm.