Nearly all cases of WHIM syndrome are attributed to heterozygous autosomal dominant mutations in the C-X-C chemokine receptor type 4 (CXCR4) gene (4), CXCR4 is widely expressed across various cell types, including mature leukocyte subtypes, epithelial cells, endothelial cells, hematopoietic progenitors, stromal fibroblasts, and cancer cells (5, 6). This evidence concerns the gene CXCR4 and cancer.