During the treatment, the most common AEs included: leucopenia, neutropenia, anemia, thrombocytopenia, alanine aminotransferase (ALT) increase, aspartate transaminase (AST) increase, creatinine increase, vomiting, peripheral neuropathy, and diarrhea, most of which were of grade 1-2 and manageable (Table 6). This evidence concerns the gene GPT and anemia (phenotype).