STAT3 and hyper-IgE syndrome: In other patients, such as those with abnormalities in LRBA protein (19), in STAT3-related HyperIgE syndrome associated with normal immunoglobulin yet abnormal B cell development (20) and variable production of specific antibodies (21), in Ataxia-Telangiectasia mutated (22) and ZTTK syndrome caused by SON haploinsufficiency (23), the number of CD19+ B cells and immunoglobulin concentrations ranged from markedly reduced to normal.