HIF1A and synovial sarcoma: Another study found that the C/T genotype (95% CI=0.09-0.52) and T allele (95% CI=0.12-0.58) of the HIF1A Pro582Ser polymorphism had a protective effect on primary SS (OR=0.22, P<0.01) and were susceptibility genetic factors for primary SS (192), further underscores the importance of HIF-1α activity in SS pathogenesis.