Secondly, we aim to explore the roles of other hypoxia-related factors in the progression of AIDs, this includes a thorough analysis of the stability and activation mechanisms of HIF-2α under hypoxic conditions, and investigating the interactions and differences between HIF-2α and HIF-1α in the progression of AIDs, to optimize therapeutic outcomes and minimize side effects through the combined administration of HIF-1α and HIF-2α inhibitors (27, 166). The gene discussed is EPAS1; the disease is AIDS.