In an antigen-induced arthritis (AIA) rat model, the administration of AMSP-30m, a HIF-1α inhibitor, was observed to elicit a marked reduction in foot swelling, arthritis index, and histopathological scores, alongside a notable decrease in the serum and synovial tissue levels of inflammatory cytokines, including IL-1β, IL-6, and TNF-α. This evidence concerns the gene HIF1A and arthritic joint disease.