It was found that in an animal model of RA, the expression levels of ACPA, IL-17A, and HIF-1α in the group subjected to hyperbaric oxygen therapy (HBOT) were significantly reduced (P<0.05) compared to the non-HBO control group (204), This finding underscores the potential anti-inflammatory effects of HBO in RA, which may be mediated through increased tissue oxygenation, reduced inflammatory cell infiltration, and suppressed inflammatory factor production. Here, PRTN3 is linked to rheumatoid arthritis.