HIF1A and systemic lupus erythematosus: Another investigation revealed that in photosensitive SLE patients, circulating miR-210 and HIF-1α levels are significantly elevated and positively correlated (r=0.886, P<0.05), and miR-210, a critical hypoxia-related molecule, can regulate hypoxic signaling within hypoxic microenvironments (151, 152).