It was found that in an animal model of RA, the expression levels of ACPA, IL-17A, and HIF-1α in the group subjected to hyperbaric oxygen therapy (HBOT) were significantly reduced (P<0.05) compared to the non-HBO control group (204), This finding underscores the potential anti-inflammatory effects of HBO in RA, which may be mediated through increased tissue oxygenation, reduced inflammatory cell infiltration, and suppressed inflammatory factor production. This evidence concerns the gene IL17A and rheumatoid arthritis.