Using distinct HIF-1α antibodies for staining macrophages, dual-positive immunofluorescence for HIF-1α+ and CD206+ macrophages was detected in proximity to capillaries (186), indicating that vascular neogenesis in jDM patients is regulated by the VEGF/HIF pathway, inducing HIF-1α and promoting CD206 expression in macrophages, which may lead to hypoxic damage to capillaries in DM patients. Here, MRC1 is linked to juvenile dermatomyositis.