It has been reported that in salivary gland tissues of SS patients and SS mouse models Th17 cells are highly increased, and HIF-1α can directly transcribe and activate RORγt to enhance Th17 development (97, 193), suggests that hypoxia may participates in the imbalance of T cell subsets and enhanced inflammation in SS. The gene discussed is HIF1A; the disease is synovial sarcoma.