SNPs in STAT4 have been reported as risk factors for the development of autoimmune diseases, including RA, SLE, lupus nephritis (LN), type 1 diabetes (T1D), psoriasis, inflammatory bowel disease (IBD), Behçet’s disease (BD), Sjögren’s syndrome (SS), systemic sclerosis (SSc), primary biliary cirrhosis (PBC), and other diseases (Table 1). Here, STAT4 is linked to inflammatory bowel disease.