STAT4 and systemic lupus erythematosus: Besides, four STAT4 variants, including rs7574865 T, rs10181656 G, rs13426947 A, and rs10168266 T, have been reported to be associated with an increased risk of NMOSD, and similar to SLE, the G allele of rs7601754 also displays a protective effect against NMOSD (137).