SNPs in STAT4 have been reported as risk factors for the development of autoimmune diseases, including RA, SLE, lupus nephritis (LN), type 1 diabetes (T1D), psoriasis, inflammatory bowel disease (IBD), Behçet’s disease (BD), Sjögren’s syndrome (SS), systemic sclerosis (SSc), primary biliary cirrhosis (PBC), and other diseases (Table 1). The gene discussed is STAT4; the disease is rheumatoid arthritis.