Based on postoperative pathology, 32 (19.1%) cases had non-functional adenomas, 19 (11.3%) cases had GH-secreting adenomas, 33 (19.6%) cases had PRL-secreting adenomas, 41 (24.4%) cases had FSH-secreting adenomas, 29 (17.3%) cases had ACTH-secreting adenomas, four (2.4%) cases had TSH-secreting adenomas, and 10 (6.0%) cases had plurihormonal adenomas (Table 1). This evidence concerns the gene POMC and adenoma.