A paraganglioma/pheochromocytoma panel of 12 genes (FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, and VHL) associated with pheochromocytoma occurrence found no clinically significant mutations, excluding the possibility of MEN syndrome, von Hippel-Lindau, neurofibromatosis type 1, and familial paraganglioma syndrome. This evidence concerns the gene VHL and multiple endocrine neoplasia.