Gastrointestinal disorders, mainly nausea and vomiting, gastroesophageal reflux, and constipation, represent some of the most frequent complaints during pregnancy probably due in part to elevated hormones such as progesterone, human chorionic gonadotropin, and/or prostaglandins, as well as increased gastrin production, and delayed gastric emptying [28]. Here, GAST is linked to gastroesophageal reflux disease.