The condition known as EIAS requires the presence of the following conditions: 1) a history of current or previous use of exogenous insulin; 2) recurring and challenging-to-manage episodes of hyperglycemia, hypoglycemia, or a combination of both; 3) significantly high levels of serum insulin with disproportionately low or reduced C-peptide levels; 4) the presence of positive insulin antibodies; and 5) the exclusion of hypoglycemia caused by other factors [5]. The gene discussed is INS; the disease is Hypoglycemia.