If the insulin dose is minimal, it may be possible to discontinue insulin and switch to medications such as alpha-glucosidase inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, and glucagon-like peptide-1 receptor agonist (GLP-1RA)to manage blood sugar levels while also preventing hypoglycemia [21,22]. This evidence concerns the gene INS and Hypoglycemia.