These crucial classes comprised key AC subtypes including EPHA6+, PTPRT+, VIP+, DRD2+, PDGFRA+, and SSTR2+, and BC subpopulations including RELN+, FEZF2+, DSCAM+, PTPRQ+, TTR+, and ERBB4+, which showed strong transcriptomic similarity to those in humans and macaques. Here, VIP is linked to breast cancer.