The multivariate analysis revealed that progression to thrombocytopenia (p = 0.042, hazard ratio (HR) = 7.7, 95% confidence interval (CI) = 1.04–7.70), ASXL1 mutation (p = 0.041, HR = 9.91, 95% CI = 1.05–9.91), and IDH1 mutation (p = 0.02, HR = 75.6, 95% CI = 5.19–1103) were associated with poor OS. The gene discussed is ASXL1; the disease is Thrombocytopenia.