Genetic evidence indicated that elevated levels of FGF19 levels (OR = 1.100, 95% CI 1.020–1.180, p = 0.030) promoted the occurrence of T2DM, and increased concentrations of FGF21 levels (OR = 0.770, 95% CI 0.610–0.960, p = 0.020), CCL19 (OR = 0.050, 95% CI 0.930–0.990, p = 0.030) levels, CCL11 levels (OR = 0.930, 95% CI 0.870–1.000, p = 0.050), and IL-10 (OR = 0.920, 95% CI 0.840–1.000, p = 0.040) mitigated the risk of developing T2DM (Figures 3, 4). The gene discussed is CCL11; the disease is type 2 diabetes mellitus.