Among individuals of European ancestry in DN dataset, the IVW analysis revealed a significant positive causal association between the gene expression of TNFSF14 (OR = 1.249, 95% CI 1.018–1.532, p = 0.033) and TRANCE (OR = 1.287, 95% CI 1.051–1.577, p = 0.015) with DN. The gene discussed is TNFSF11; the disease is liver dysplastic nodule.