Proteomic studies have established that SMOC1 levels in the human brain and CSF strongly correlate with Aβ levels [10, 50, 51, 96, 98, 102, 113, 116, 118, 128] and SMOC1 has been identified as a strong AD-specific biomarker candidate either in isolation [50, 118, 128] or within a protein panel [50, 51, 87, 109]. The gene discussed is SMOC1; the disease is Alzheimer disease.