SMOC1 and neurodegenerative disease: SMOC1 is significantly increased in the CSF of AD patients when compared to cognitively normal controls [28, 31, 32, 50, 51, 54, 96, 109, 113, 116, 118, 128] or other neurodegenerative diseases [30, 32, 77, 98, 107, 112, 121].