Increased SMOC1 expression is only reported in other neurodegenerative diseases when Aβ is present (e.g. Lewy Body Dementia) and correlates to Aβ pathology load rather than cognitive decline in AD [64, 65, 94, 118, 119, 128], suggesting that the SMOC1 increase is linked specifically to Aβ rather than AD pathogenesis more broadly. The gene discussed is SMOC1; the disease is Alzheimer disease.