Proteins with EF-hand calcium binding domains similar to SMOC1 such as calbindin, parvalbumin, S100B, and calretinin have all been implicated in AD [8, 18, 21, 27, 52, 56–59, 78, 86, 93, 100, 103, 125]. The gene discussed is PVALB; the disease is Alzheimer disease.