Given the limited prior analysis of the distribution and role of SMOC1 in AD, the aims of this study were to perform a detailed neuropathological study of SMOC1 changes in human brain tissue throughout the spectrum of AD, to determine if SMOC1 interacted with Aβ or phosphorylated tau in human AD brain tissue, and to determine if SMOC1 influenced aggregation of Aβ. Here, MAPT is linked to Alzheimer disease.