SMOC1 and early-onset autosomal dominant Alzheimer disease: SPARC-related modular calcium-binding protein 1 (SMOC1) has been shown to be one of the most dysregulated proteins in Alzheimer’s disease (AD) brain tissue, cerebrospinal fluid (CSF) and plasma in 23 proteomic analyses to date [9, 10, 22, 28, 29, 32, 51, 54, 66, 67, 87, 88, 96, 98, 99, 102, 104, 113, 116, 118, 120, 121, 128].